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Macroprolactinemia as a cause of hyperprolactinemia. Series of cases

Macroprolactinemia como causa de hiperprolactinemia. Serie de casos

VOLUMEN 4 - NÚMERO 2 / Abril - Junio (Artículo Original)


Sandra I. Rodríguez-Carranza, Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Paloma Almeda-Valdés, Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Ciudad de México, México
Nicole M. Iñiguez-Ariza, Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
David Roberto Chavira-Ramírez, Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Francisco J. Gómez-Pérez, Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Ciudad de México, México

Macroprolactinemia is defined as the presence of prolactin with a molecular weight greater than 150 kDa. It can be confused with idiopathic hyperprolactinemia or with a prolactinoma. It is considered a benign variant and does not require medical treatment or follow-up. The objective of this article is to describe a series of patients with macroprolactinemia as a cause of hyperprolactinemia. Among fourteen cases, macroprolactinemia was found in eight (57.1%) and the majority (87.5%) presented with symptoms. Macroprolactinemia was frequent in this series of cases. The assessment of macroprolactinemia is useful in cases with apparently idiopathic hyperprolactinemia.

Palabras clave: Macroprolactinemia. Hyperprolactinemia. Prolactinoma.

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