Relationship between insulin resistance and hypercortisolism: HAIR-AN syndrome mimicking cushing´s syndrome

Roxana P. Gómez-Ruiz, Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Miguel A. Gómez-Sámano, Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

HAIR-AN syndrome, defined by hyperandrogenism, insulin resistance (IR), and acanthosis nigricans, is a rare subset of polycystic ovary syndrome characterized by more severe IR and an increased risk of metabolic complications. We present a case of a female in her early 20s with initially displayed signs of hypercortisolism – central obesity, hirsutism, and IR – symptoms that can overlap with Cushing´s syndrome. The coexistence of IR and hypercortisolism can make the diagnosis and management of these patients particularly challenging.

Keywords: HAIR-AN syndrome. Cushing syndrome. Insulin resistance. Hypercortisolism.