Effect of the rs9939609-FTO marker in Mexican adults under nutritional intervention

Diana A. Vela-Vásquez, Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica, Instituto Politécnico Nacional (IPN), Reynosa, Tamps., Mexico
Ivan Delgado-Enciso, Facultad de Medicina, Universidad de Colima, Colima, Mexico
Gilberto Ruiz-de-la-Cruz, Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica, Instituto Politécnico Nacional (IPN), Reynosa, Tamps., Mexico
Pascuala Ambriz-Morales, Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica, Instituto Politécnico Nacional (IPN), Reynosa, Tamps., Mexico
Ana Ma. Sifuentes-Rincón, Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica, Instituto Politécnico Nacional (IPN), Reynosa, Tamps., Mexico

Background: Obesity is a disease importantly influenced by genetic factors. The rs9939609 variant of the gene associated with fat mass and obesity (FTO) has been associated with weight gain, body mass index (BMI), and influence on the individual response to macronutrient intake. Objectives: To evaluate the effect of the rs9939609-FTO (A>T) marker on the response of volunteers under a dietary intervention that included beef with different compositions: high in saturated fatty acids and high in monounsaturated fatty acids (MUFA). Methods: The rs9939609-FTO marker genotype was obtained from 49 volunteers under a dietary intervention, and parametric tests were performed to determine its influence on anthropometric measurements between genotypes. Results: Both groups showed reductions in post-intervention measurements. The rs9939609-FTO polymorphism had no significant impact on weight loss, except at the hip measurement, where the A allele carriers (TA/AA) those that consumed more MUFA showed significantly smaller reductions between genotypes. Conclusion: This study provides insights from a Mexican population about the influence of FTO genotypes and diet composition on weight loss.

Keywords: Saturated fatty acids. Monounsaturated fatty acids. Weight loss. Body mass index. Single-nucleotide polymorphism.